2C-E is commonly active in the 10–20 mg range, taken orally, and highly dose-sensitive. Insufflating (administering the chemical nasally) requires a much lower dose, typically not exceeding 5mgs, but this method of consumption elicits a noticeably painful or uncomfortable sensation in the nasal cavity for 10 minutes or so. Alexander Shulgin classified 2C-E as a member of the “magical half-dozen” in his book PiHKAL .
