No deaths have been attributed to 2C-I and several large doses (100+ milligrams) have been survived. There have been no reports of physical dependence or addiction, which is predictable, as chemically similar compounds have exhibited little potential for dependency. 2C-I may include iodine, which can cause thyroid damage. Large doses of 2C-I, like other phenylalanines, may result in undesirable psychological effects, the persistence and severity of which are largely undocumented.